Effects of Dual Cyclooxygenase-2 and Carbonic Anhydrase Inhibition

CG100649 capsules: 2 mg, single oral administration (Part 1); CG100649 capsules: dose to be determined, single oral administration (the single CG100649 dose level used in Part 3 will be determined by part 1 and 2).

Celecoxib (Celebrex®) capsules: 200 mg; single oral administration (Part 1 and 3)

Placebo capsules: 198 mg silicified microcrystalline cellulose + 2 mg talc, multiple oral administrations (Part 1 and 3)

Naproxen (Naprosyn®) tablets: 500 mg, single oral administration (Part 3)

Acetazolamide (generic, immediate release) tablets: 250 mg, single oral administration (Part 3)

CG100649 capsules: 8 mg, single oral administration (Part 1); CG100649 capsules: dose to be determined, single oral administration (the single CG100649 dose level used in Part 3 will be determined by part 1 and 2).