8
Participants
Start Date
October 31, 2008
Primary Completion Date
March 31, 2011
Study Completion Date
March 31, 2011
sorafenib
Sorafenib will be administered daily starting day 1 at 200mg QOD at Dose Level 1; 200mg/day at Dose Level 2; 200mg BID (5 days on/ 2 days off) at Dose Level 3; 200mg BID at Dose Level 4; and 400mg BID at Dose Level 5.
bevacizumab
Bevacizumab will be administered as 5mg/kg IV on Day 1 of each treatment cycle.
mFOLFOX6 regimen
The mFOLFOX6 regimen will be administered on Day 1 of each treatment cycle. This regimen consists of oxaliplatin 85 mg/m2 IV given over 2 hours, leucovorin 400 mg/m2 IV given over 2 hours, and fluorouracil 400 mg/m2 IV bolus, followed by fluorouracil 1200 mg/m2 per day for 2 days continuous infusion.
Central Georgia Cancer Care, Macon
The West Clinic, Memphis
Hematology Oncology Centers of the Northern Rockies, Billings
Collaborators (1)
Bayer
INDUSTRY
Accelerated Community Oncology Research Network
OTHER