Treatment of Systemic Lupus Erythematosus (SLE) With N-acetylcysteine

PHASE2RecruitingINTERVENTIONAL
Enrollment

290

Participants

Timeline

Start Date

May 5, 2022

Primary Completion Date

March 31, 2027

Study Completion Date

September 30, 2028

Conditions
Systemic Lupus Erythematosus
Interventions
DRUG

N-acetylcysteine

Capsules of NAC, each containing 600 mg of NAC between dosages of 2.4 g to 4.8 g daily

DRUG

Placebo

placebo (sugar) twice daily, daily dosage will match that of NAC that was tolerated between daily dosages of 2.4 g and 4.8 g during the open-label titration phase.

Trial Locations (8)

10021

RECRUITING

Hospital for Special Surgery, New York

13210

RECRUITING

SUNY Upstate Medical University, Syracuse

17033

RECRUITING

Penn State MS Hershey Medical Center, Hershey

18102

RECRUITING

St. Luke's University Health Network, Allentown

43210

RECRUITING

The Ohio State University, Columbus

73104

RECRUITING

VA Medical Center, Oklahoma City

90048

RECRUITING

Cedars-Sinai Medical Center, Los Angeles

06519

RECRUITING

Yale Center for Clinical Investigation, New Haven

All Listed Sponsors
collaborator

Cedars-Sinai Medical Center

OTHER

collaborator

University of Rochester

OTHER

collaborator

Yale University

OTHER

collaborator

Penn State University

OTHER

collaborator

Hospital for Special Surgery, New York

OTHER

collaborator

Ohio State University

OTHER

collaborator

Oklahoma City VA Health Care System

FED

collaborator

St. Luke's Hospital and Health Network, Pennsylvania

OTHER

lead

State University of New York - Upstate Medical University

OTHER