Anti-Cytokine Therapy for Vasculitis

5 mg/kg intravenous infusion at weeks 0, 2, 6 and 10 of study

Daily oral 2 mg/kg or pulsed intravenous 15mg/kg every 2-3 weeks for 3-6 months (until patient has been in remission for 3 months).

Daily oral 1mg/kg tapered over 12 months

Daily oral 2 mg/kg started once patient is in remission and cyclophosphamide has been discontinued.

Additional therapy for patients with severe vasculitis (creatinine \> 500 mcmol/L or pulmonary haemorrhage). 7x 4L exchanges over 10 days.

Daily oral up to 1.5 g twice daily as tolerated. Used as alternative to azathioprine at lead physicians discretion.

500 mg intravenous infusion daily for three days at lead physicians discretion.