Vorinostat, Bortezomib, and Doxorubicin Hydrochloride Liposome in Treating Patients With Relapsed or Refractory Multiple Myeloma

PHASE1TerminatedINTERVENTIONAL
Enrollment

32

Participants

Timeline

Start Date

October 31, 2008

Primary Completion Date

December 31, 2011

Study Completion Date

April 30, 2015

Conditions
Multiple Myeloma and Plasma Cell Neoplasm
Interventions
DRUG

bortezomib

Intravenous Push 1.3 mg/m2 Days 1, 4, 8, and 11

DRUG

pegylated liposomal doxorubicin hydrochloride

Intravenous infusion, 30mg/m2, Day 4, each cycle

DRUG

vorinostat

Oral, 300mg, Days 1, 2, 4, 5, 8, 9, 11, 12, every cycle.

Trial Locations (4)

10029

Mount Sinai Medical Center, New York

27710

Duke Comprehensive Cancer Center, Durham

27599-7295

Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill, Chapel Hill

27157-1096

Wake Forest University Comprehensive Cancer Center, Winston-Salem

All Listed Sponsors
collaborator

Merck Sharp & Dohme LLC

INDUSTRY

collaborator

Millennium Pharmaceuticals, Inc.

INDUSTRY

collaborator

Ortho Biotech, Inc.

INDUSTRY

lead

UNC Lineberger Comprehensive Cancer Center

OTHER