Safety and Tolerability of Single and Multiple Doses of ISIS 353512 in Healthy Volunteers

50 mg via 2 hour IV infusion, single dose

50 mg via 2 hour IV infusion, 6 doses over 22 days

50 mg via SC injection, single dose

50 mg via SC injection, 6 doses over 22 days

2 hour IV infusion, 50 mg on day 3, 100 mg on day 5, and 200 mg on day 8

100 mg via 2 hour IV infusion, single dose

200 mg via 2 hour IV infusion, single dose

100 mg via SC injection, single dose

200 mg via SC injection, single-dose

100 mg via 2 hour IV infusion, 6 doses over 22 days

200 mg via 2 hour IV infusion, 6 doses over 22 days

100 mg via SC injection, 6 doses over 22 days

200 mg via SC injection, 6 doses over 22 days

100 mg via SC injection PLUS an oral treatment of a NSAID, acetaminophen, or oral placebo

200 mg via SC injection PLUS an oral treatment of a NSAID, acetaminophen, or steroid

2 hour IV infusion, 50 mg on day 1, 100 mg on day 3, 100 mg on day 5 and 200mg on day 8