NCT00732888 - Effect of Calcium on Tasigna Pharmacokinetics (PK) in Healthy Volunteers | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

November 30, 2008

Primary Completion Date

August 31, 2011

Study Completion Date

September 30, 2011

Conditions

Healthy

Interventions

DRUG

Nilotinib Hydrochloride

Dosage form: capsules Dosage: 400 mg (2 x 200 mg capsule) Frequency \& duration: On an 18-day schedule, one dose administered once on day 1 and once on day 15 (2 doses total)

DIETARY_SUPPLEMENT

calcium carbonate

Dosage form: tablets Dosage: 4000 mg (4 x 1000 mg tablet) Frequency: On an 18-day schedule, once daily day 15 (for Arm 1); or once daily day 1 (for Arm 2)

Trial Locations (1)

15232

University of Pittsburgh Cancer Institute / Clinical and Translational Research Center (Hillman Cancer Center and Montefiore University Hospital locations), Pittsburgh