Phase I, Pharmacokinetic, Pharmacodynamic Trial of PTK787 and Paclitaxel in Combination for Advanced Solid Tumors

PHASE1CompletedINTERVENTIONAL
Enrollment

28

Participants

Timeline

Start Date

May 31, 2005

Primary Completion Date

September 30, 2008

Study Completion Date

August 31, 2010

Conditions
Neoplasm MetastasisCarcinoma
Interventions
DRUG

Paclitaxel plus PTK787

"Paclitaxel will be given on days 1 and 15 over 28 days in cycle 1 with PTK787 on days 3 to 28. PTK787 WILL BE TAKEN AT NIGHT.~In cycle 2 and beyond, paclitaxel will be given on days 1, 8 and 15 every 28 days . PTK787 will be taken orally NIGHTLY."

Trial Locations (1)

46202

Indiana University Simon Cancer Center, Indianapolis

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Novartis

INDUSTRY

lead

Indiana University School of Medicine

OTHER