A Study To Test The Impact Of PF- 00299804 On How The Body Handles Dextromethorphan In Cancer Patients

PHASE1CompletedINTERVENTIONAL
Enrollment

16

Participants

Timeline

Start Date

September 30, 2008

Primary Completion Date

April 30, 2011

Study Completion Date

July 31, 2014

Conditions
Advanced Malignant Solid Tumors
Interventions
DRUG

PF-00299804

PF-00299804: Patients take oral 45 mg PF-00299804 once daily starting on Cycle 1 Day 1 until disease progression or unacceptable toxicities occur. One cycle equals 21 days. Dextromethorphan: Patient take a single 30 mg oral dose of dextromethorphan HBr three days prior to Cycle 1 Day 1, and then on Cycle 2 Day 7.

Trial Locations (2)

14263

Roswell Park Cancer Institute, Buffalo

78229

South Texas Accelerated Research Therapeutics, LLC, San Antonio

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Roswell Park Cancer Institute

OTHER

collaborator

South Texas Accelerated Research Therapeutics (START)

UNKNOWN

lead

Pfizer

INDUSTRY