Safety and Efficacy Study of Eculizumab in Patients With Refractory Generalized Myasthenia Gravis

PHASE2TerminatedINTERVENTIONAL
Enrollment

14

Participants

Timeline

Start Date

October 31, 2008

Primary Completion Date

March 31, 2011

Study Completion Date

July 31, 2011

Conditions
Myasthenia Gravis
Interventions
DRUG

eculizumab

eculizumab 600 mg IV weekly for 4 doses followed by eculizumab 900 mg IV every two weeks for 7 doses

DRUG

Placebo

Placebo IV weekly for 4 doses then every two weeks for 7 doses

Trial Locations (25)

21287

Johns Hopkins University School of Medicine, Baltimore

27710

Duke University Medical Center, Durham

30322

Emory University, Atlanta

32209

University of Florida & Shands Neuroscience Institute, Jacksonville

35233

University of Alabama at Birmingham, Birmingham

37232

Vanderbilt University Medical Center, Nashville

43210

The Ohio State University, Columbus

46202

Wishard Hospital, Indianapolis

48201

Wayne State University, Detroit

66160

University of Kansas Medical Center, Kansas City

75390

University of Texas Southwestern Medical School, Dallas

92868

University of California, Irvine, Orange

95817

University of California - Davis, Sacramento

02114

Massachusetts General Hospital, Boston

02135

Caritas St. Elizabeths' Medical Center, Boston

10029-6574

Mount Sinai School of Medicine, New York

27599-1651

University of North Carolina at Chapel Hill, Chapel Hill

44106-5098

University Hospitals - Case Medical Center, Cleveland

02905

The Warren Alpert Medical School of Brown University, Providence

05405

The University of Vermont College of Medicine, Burlington

22908-0394

University of Virginia, Charlottesville

Unknown

The Northern Alberta Clinical trials and Research Centre, Edmonton

Institute of Neurological Sciences, Department of Neurology, Southern General Hospital,, Glasgow

Institute of Neurology, London

Department of Clinical Neurology, West Wing, John Radcliffe Hospital, Oxford

Sponsors
All Listed Sponsors
lead

Alexion Pharmaceuticals, Inc.

INDUSTRY