A Phase 1/2, Multi-center, Open-label, Dose-escalation Study of Elotuzumab(Humanized Anti-CS1 Monoclonal IgG1 Antibody) and Bortezomib in Subjects With Multiple Myeloma Following One to Three Prior Therapies.

PHASE1TerminatedINTERVENTIONAL
Enrollment

28

Participants

Timeline

Start Date

May 31, 2008

Primary Completion Date

March 31, 2012

Study Completion Date

March 31, 2012

Conditions
Multiple Myeloma
Interventions
DRUG

Elotuzumab (HuLuc63)

Cohort 1 - 2.5 mg/kg elotuzumab IV with bortezomib on Days 1 \& 11, with only Bortezomib IV on Days 4 \& 8; Cohort 2 - 5.0 mg/kg elotuzumab IV with bortezomib on Days 1 \& 11, with only Bortezomib IV on Days 4 \& 8; Cohort 3 - 10.0 mg/kg elotuzumab IV withbortezomib on Days 1 \& 11, with only Bortezomib IV on Days 4 \& 8; and Cohort 4 - 20.0 mg/kg elotuzumab IV with bortezomib on Days 1 \& 11, with only Bortezomib IV on Days 4 \& 8.

Trial Locations (8)

14263

Site Reference ID/Investigator# 63850, Buffalo

43210

Site Reference ID/Investigator# 63849, Columbus

60637

Site Reference ID/Investigator# 63855, Chicago

90033

Site Reference ID/Investigator# 63853, Los Angeles

98109

Site Reference ID/Investigator# 63848, Seattle

02115

Site Reference ID/Investigator# 63847, Boston

48109-5936

Site Reference ID/Investigator# 63852, Ann Arbor

07601

Site Reference ID/Investigator# 63854, Hackensack

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Bristol-Myers Squibb

INDUSTRY

lead

Abbott

INDUSTRY