A Study of Effectiveness and Safety of CNTO 136 in Patients With Active Rheumatoid Arthritis Despite Methotrexate Therapy

PHASE2CompletedINTERVENTIONAL
Enrollment

187

Participants

Timeline

Start Date

August 11, 2008

Primary Completion Date

March 3, 2011

Study Completion Date

March 3, 2011

Conditions
Arthritis, Rheumatoid
Interventions
DRUG

CNTO 136 100 mg

CNTO 136 100 mg will be administered subcutaneously (under the skin) every 2 or 4 weeks as per the appropriate randomized arm.

DRUG

CNTO 136 50 mg

CNTO 136 50 mg will be administered subcutaneously every 4 weeks from Week 0 to Week 24.

DRUG

CNTO 136 25 mg

CNTO 136 25 mg will be administered subcutaneously every 4 weeks from Week 0 to Week 24.

DRUG

Placebo

Placebo will be adminstered subcutaneously as per the appropriate randomized arm.

DRUG

Methotrexate

Stable dose of methotrexate will be maintained through Week 24.

Trial Locations (38)

Unknown

Aventura

Lexington

Frederick

Kalamazoo

Charlotte

Winston-Salem

Duncansville

Anderson

Budapest

Győr

Kecskemét

Goshogawara

Hitachi

Kawagoe

Kitakyushu

Miyazaki

Sasebo

Shinjuku-Ku

Tomigusuku

Guadalajara

Mexico City

México

Bialystok

Bydgoszcz

Elblag

Gdynia

Krakow

Lublin

Poznan

Warsaw

Kemerovo

Moscow

Novosibirsk

Saint Petersburg

Busan

Daegu

Daejeon

Seoul

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Centocor, Inc.

INDUSTRY