Certolizumab Pegol for the Treatment of Patients With Active Rheumatoid Arthritis

PHASE3CompletedINTERVENTIONAL
Enrollment

1,648

Participants

Timeline

Start Date

July 31, 2008

Primary Completion Date

March 31, 2010

Study Completion Date

March 31, 2011

Conditions
Rheumatoid Arthritis
Interventions
DRUG

Certolizumab pegol (CZP)

400 mg CZP given as two 200 mg subcutaneous (sc) injections at Weeks 0, 2, and 4, followed by 200 mg CZP given as 1 sc injection on Weeks 6, 8, and 10. At Week 12 subjects enter the open label phase and receive 200 mg of CZP every other week for a minimum 16 additional weeks until CZP is commercially available.

OTHER

Placebo

Placebo (0.9% saline) given as 2 subcutaneous (sc) injections at Weeks 0, 2, and 4, followed by placebo given as 1 sc injection on Weeks 6, 8, and 10. At Week 12 subjects enter the open label phase and receive 200 mg of CZP every other week for a minimum 16 additional weeks until CZP is commercially available.

Trial Locations (181)

Unknown

Birmingham

Montgomery

Phoenix

Tucson

Hot Springs

Little Rock

Fullerton

La Jolla

Los Angeles

Palm Desert

Sacramento

Santa Barbara

Santa Maria

Tustin

Westlake Village

Whittier

Denver

Danbury

Trumbull

Lewes

Newark

Washington D.C.

Boca Raton

Delray Beach

Gainesville

Jacksonville

Orlando

South Miami

Tampa

Tavares

Atlanta

Coeur d'Alene

Idaho Falls

Maywood

Peoria

Rock Island

Springfield

Evansville

Indianapolis

Wichita

Louisville

Covington

Lake Charles

Baltimore

Columbia

Frederick

Wheaton

Boston

Fall River

Battle Creek

Kalamazoo

Lansing

Petoskey

Duluth

Rochester

St Louis

New Brunswick

Voorhees Township

Albany

New York

Orchard Park

Rochester

Roslyn

Smithtown

Syracuse

The Bronx

Asheville

Chapel Hill

Charlotte

Monroe

Wilmington

Columbus

Dayton

Fairfield

Mayfield

Oklahoma City

Erie

Philadelphia

Pittsburgh

West Reading

Wexford

Charleston

Jackson

Amarillo

Austin

Dallas

Fort Worth

Houston

Lubbock

San Antonio

Sugar Land

Salt Lake City

Newport News

Richmond

Spokane

Tacoma

Yakima

Clarksburg

Glendale

Milwaukee

Monroe

Edmonton

Vancouver

Winnipeg

St. John's

Halifax

Hamilton

Kitchener

London

Toronto

Windsor

Montreal

Rimouski

Trois-Rivires

Calgary

Mississauga

Newmarket

Sainte-Foy

Amiens

Cahors

Corbeil-Essonnes

Dreux

Liévin

Montpellier

Mulhouse

Nantes

Orléans

Paris

Pierre-Bénite

Rennes

Saint-Priest-en-Jarez

Bad Neuenahr

Baden

Berlin

Chemnitz

Cologne

Dresden

Duisburg

Erfurt

Erlangen

Freiburg im Breisgau

Friedrichroda

Goslar

Hamburg

Hildesheim

Hoyerswerda

Jena

Kiel

Leipzig

Mainz

München

Neuss

Osnabrück

Rostock

Wiesbaden

Zerbst

Bologna

Genova

Iesi

Modena

Palermo

Pisa

Prato

Siena

Udine

Apeldoorn

Arnhem

Leiden

The Hague

A Coruña

Barcelona

Madrid

Murcia

Oviedo

Pontevedra

Sabadell

Salamanca

San Cristóbal de La Laguna

Santander

Santiago de Compostela

Torrelavega

Sponsors

Lead Sponsor

All Listed Sponsors
lead

UCB Pharma

INDUSTRY

NCT00717236 - Certolizumab Pegol for the Treatment of Patients With Active Rheumatoid Arthritis | Biotech Hunter | Biotech Hunter