A Study of Mapatumumab in Combination With Sorafenib in Subjects With Advanced Hepatocellular Carcinoma

PHASE1CompletedINTERVENTIONAL
Enrollment

23

Participants

Timeline

Start Date

June 30, 2008

Primary Completion Date

August 31, 2011

Study Completion Date

August 31, 2012

Conditions
Hepatocellular Carcinoma
Interventions
BIOLOGICAL

mapatumumab

3, 10, or 30 mg/kg IV (in the vein), on day 1 of each 21 day cycle

DRUG

sorafenib

400 mg orally, twice a day continuously in each cycle

Trial Locations (6)

19104

University of Pennsylvania- Abramson Cancer Center, Philadelphia

27599

UNC Lineberger Comprehensive Cancer Center, Chapel Hill

32610

University of Florida, Gainesville

55905

Mayo Clinic, Rochester

80045

University of Colorado Cancer Center, Aurora

90048

Cedars-Sinai Health System, Los Angeles

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

GlaxoSmithKline

INDUSTRY

lead

Human Genome Sciences Inc., a GSK Company

INDUSTRY

NCT00712855 - A Study of Mapatumumab in Combination With Sorafenib in Subjects With Advanced Hepatocellular Carcinoma | Biotech Hunter | Biotech Hunter