Morphine After Radiofrequency Ablation of Painful Bone Metastases in Patients With Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

78

Participants

Timeline

Start Date

December 24, 2007

Primary Completion Date

February 11, 2016

Study Completion Date

March 16, 2016

Conditions
Metastatic CancerPainUnspecified Adult Solid Tumor, Protocol Specific
Interventions
DRUG

Acetaminophen

Intravenous administration of paracetamol (4 g / 24h) and patient-controlled analgesia (PCA).

DRUG

Morphine Sulfate

Patient-controlled analgesia (PCA), allowing morphine consumption to be titrated to the patient's needs and thus allowing morphine doses to be adapted to an increase in pain in the patient's post-operative period or a rapid analgesic effect of radiofrequency.

OTHER

Questionnaire administration

"Pain notebook will allow the patient to describe the pain specific to the metastasis concerned, containing information on :~* The intensity of the minimum, average and maximum pain of the last 24 months. hours as well as the intensity of the pain of the moment according to a scale 11-point digital,~* the background morphine analgesic treatment during the last 24 hours,~* the morphine analgesic treatment taken during painful attacks,~* the possible undesirable effects of morphine treatment.~* the morphinic, non-morphinic and co-antalgic treatment is noted, as well as that the total dose of oral morphine or oral morphine equivalent"

PROCEDURE

Quality-of-life assessment

Patients' quality of life will be assessed using the quality of life questionnaire EORTC QLQ-C30 at inclusion in the study and at 8 weeks after radiofrequency. ablation.

PROCEDURE

Radiofrequency ablation

"Recent technique of thermal destruction of tumors.~This technique consists of inserting an electrode needle into the tumour under X-ray or ultrasound guidance or intraoperatively under laparoscopy for example. This needle carries a current or a light wave depending on the characteristics of the generator to which it is connected (radiofrequency, laser).~Radio frequencies are radiation non-ionising electromagnets. In this context of tissue ablathermia wavelengths ranging from 400kHz to 500kHz."

Trial Locations (1)

33076

Institute Bergonié, Bordeaux

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Institut Bergonié

OTHER