Dose Escalation Study of CAL-101 in Select Relapsed or Refractory Hematologic Malignancies

PHASE1CompletedINTERVENTIONAL
Enrollment

192

Participants

Timeline

Start Date

June 30, 2008

Primary Completion Date

December 31, 2011

Study Completion Date

August 31, 2012

Conditions
Chronic Lymphocytic Leukemia (CLL)Lymphoma, Non-Hodgkin (NHL)Acute Myeloid Leukemia (AML)Multiple Myeloma (MM)
Interventions
DRUG

CAL-101

CAL-101 50, 100, 150, 200, 350 mg capsules BID for 28 days CAL-101 150, 300 mg QD for 28 days CAL-101 150 mg BID 3 weeks on 1 week off for 28 days

Trial Locations (9)

10021

Weill Medical College of Cornell, New York

21231

The Sidney Kimmel Comprehensive Cancer Center at John Hopkins, Baltimore

37203

Sarah Cannon Research Institute, Nashville

43210

The Ohio State University Medical Center, Columbus

63110

Washington University School of Medicine, St Louis

94304-5548

Stanford Cancer Center, Palo Alto

02115

Dana-Farber Cancer Institute, Boston

97239-3098

Oregon Health and Science University, Portland

53792-5156

University of Wisconsin, Madison

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Gilead Sciences

INDUSTRY