Pharmacokinetic Study of Oral Testosterone (T) Ester Formulations in Hypogonadal Men

PHASE2CompletedINTERVENTIONAL
Enrollment

29

Participants

Timeline

Start Date

June 30, 2008

Primary Completion Date

December 31, 2008

Study Completion Date

August 31, 2009

Conditions
Hypogonadism
Interventions
DRUG

Oral testosterone undecanoate (TU) (300 mg T equivalents/dose)

Three capsules each containing 100 mg testosterone (T) as TU, BID. 300 mg T equivalents BID 30 minutes after initiation of breakfast and dinner meals for 7 days. A 7-14 day washout period occurred between successive Treatment Periods.

DRUG

Oral testosterone undecanoate (TU) combined with testosterone enanthate (TE) (400 mg T equivalents/dose)

Two capsules each containing 100 mg T as TU and 100 mg T as TE, BID. 400 mg T equivalents BID 30 minutes after initiation of breakfast and dinner meals for 7 days. A 7-14 day washout period occurred between successive Treatment Periods.

DRUG

Oral testosterone undecanoate (TU) (200 mg T equivalents/dose with and without food)

Two capsules each containing 100 mg T as TU, BID for 8 days. 200 mg T equivalents BID 30 minutes after initiation of meals (breakfast and dinner), except for Day 8 when the morning dose was administered fasting. A 7-14 day washout period occurred between successive Treatment Periods.

DRUG

Oral testosterone undecanoate (TU) combined with testosterone enanthate (TE) (300 mg T equivalents/dose)

Two capsules each containing 150 mg T as TU and 150 mg T as TE, BID. 300 mg T equivalents BID 30 minutes after initiation of breakfast and dinner meals for 7 days.

Trial Locations (4)

35235

Alabama Clinical Therapeutics, Birmingham

Alabama Internal Medicine, Birmingham

78229

dgd Research, Inc., San Antonio

90502

Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Los Angeles

Sponsors
All Listed Sponsors
collaborator

Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center

OTHER

lead

Clarus Therapeutics, Inc.

INDUSTRY

NCT00695110 - Pharmacokinetic Study of Oral Testosterone (T) Ester Formulations in Hypogonadal Men | Biotech Hunter | Biotech Hunter