Targeted Intensification With ZBEAM and Autologous Stem Cell Transplantation in Patients With High-grade B-Cell Lymphoma

PHASE2CompletedINTERVENTIONAL
Enrollment

75

Participants

Timeline

Start Date

August 31, 2007

Primary Completion Date

January 31, 2011

Study Completion Date

January 31, 2014

Conditions
Lymphoma, Large Cell, Diffuse
Interventions
DRUG

ZBEAM (Zevalin, BCNU, Etoposide, Aracytine, Melphalan)

Zevalin 0.4 mCi/kg: D-14 BCNU 300 mg/m² : D-6 Etoposide 100 mg/m²/12h : D-6 D-5 D-4 D-3 Aracytine 200 mg/m²/12h : D-6 D-5 D-4 D-3 Melphalan 140 mg/m²: D-2

PROCEDURE

ASCT

ASCT : D0

DRUG

Rituximab

Rituximab 250 mg/m² :D-21 D-14

Trial Locations (1)

75010

service d'onco hématologie adultes, hôpital Saint Louis, Paris

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Bayer

INDUSTRY

lead

Lymphoma Study Association

OTHER