Safety Study of IL-7 in Recipients of a Hemopoietic Stem Cell Transplant Peripheral Blood Stem Cell Transplant

PHASE1CompletedINTERVENTIONAL
Enrollment

12

Participants

Timeline

Start Date

March 31, 2008

Study Completion Date

April 30, 2011

Conditions
AMLCMLMDS
Interventions
DRUG

CYT107 - Recombinant glycosylated human interleukin 7.

Patients will be treated with CYT107 60 to 210 days post transplantation, in 3 successive cohorts of 3 patients. Escalating doses of CYT107 will be given to successive cohorts. Patients will receive 1 dose of CYT107 by the subcutaneous route, once a week for 3 weeks. Dose level 1: 10 mcg/kg/dose for 3 doses; Dose level II: 20 mcg/kg/dose for 3 doses; Dose level III: 30 mcg/kg/dose for 3 doses. Only 1 treatment course for this initial study.

DRUG

rhIL-7 (CYT107)

10, 20, or 30 mcg/kg once a week for 3 consecutive weeks via the subcutaneous route.

Trial Locations (1)

10065

Memorial Sloan-Kettering Cancer Institute, New York

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Cytheris, Inc.

INDUSTRY