644
Participants
Start Date
July 31, 2000
Primary Completion Date
April 30, 2011
Study Completion Date
April 30, 2013
Stable Isotope Infusion study
Stable isotope infusion study to be done following each surgery. Tagged isotopes to assess uptake into blood and tissues. Includes collection of blood and tissues (muscle)
Insulin High Dose
Insulin IV administered continuously throughout hospitalization until wounds are 95% healed.
oxandrolone
Oxandrolone given daily throughout hospitalization until 95% wound healing.
Propranolol
Propranolol to be given daily throughout hospitalization until 95% wound healing.
Growth Hormone
Recombinant Human Growth hormone to be administered daily until 95% wound healing.
Insulin Low Dose
Insulin administered IV until 95% wound healing
IGF-1/IGFBP-3
Insulin Like Growth Factor-1/Insulin like Growth Factor Binding Protein 3 administered until 95% wound healing
Itraconazole
Itraconazole administered until 95% wound healing
Growth Hormone and Propranolol
Growth Hormone and Propranolol given until 95% wound healing
Oxandrolone and Propranolol
Oxandrolone and Propranolol
Placebo or Control
Administration of Placebo or Control until 95% wound healing
University of Texas Medical Branch, Galveston
National Institute of General Medical Sciences (NIGMS)
NIH
The University of Texas Medical Branch, Galveston
OTHER