Role of TLR4 in Environmental Asthma

PHASE1CompletedINTERVENTIONAL
Enrollment

855

Participants

Timeline

Start Date

September 30, 2001

Primary Completion Date

August 31, 2006

Study Completion Date

April 30, 2008

Conditions
Asthma
Interventions
BIOLOGICAL

Lipopolysaccharide endotoxin

"Delivered in nebulized form expressed in activity units(endotoxin units -EU).~Subjects receive each dose 30 min after completing the previous dose, dose duration is approximately 10 minutes:~Challenge One first saline then 5000 EU 10,000 EU 20,000 EU~Challenge 1 and 2 must be at least 2 weeks apart.~Challenge 2 Saline 40,000 EU 80,000 EU"

Trial Locations (1)

27710

Duke University Medical Center, Durham

All Listed Sponsors
lead

John Sundy

OTHER

NCT00671892 - Role of TLR4 in Environmental Asthma | Biotech Hunter | Biotech Hunter