Efficacy Study of CYT997 in Combination With Carboplatin in Glioblastoma

PHASE1/PHASE2TerminatedINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

November 30, 2009

Primary Completion Date

June 30, 2011

Study Completion Date

June 30, 2011

Conditions
Glioblastoma Multiforme
Interventions
DRUG

CYT997

Escalating doses (100mg/m\^2 to 150mg/m\^2), 24-hour intravenous infusion on Day 2 of a 21-day cycle (Phase Ib component). Dose selected in Phase Ib component to be used for Phase II component.

DRUG

Carboplatin

Intravenous infusion over 1 hour at area under the concentration-time curve (AUC)=5 on Day 1 of a 21-day cycle

Trial Locations (4)

2065

Royal North Shore Hospital, St Leonards

3168

Monash Medical Centre, Melbourne

4215

Gold Coast Hospital, Southport

5042

Flinders Medical Centre, Bedford Park

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Gilead Sciences

INDUSTRY