55
Participants
Start Date
June 2, 2004
Primary Completion Date
January 24, 2012
Study Completion Date
January 24, 2012
Aspirin First
Crossover period Aspirin First: Subjects will receive 81 mg aspirin at approximately 8 am followed by acetaminophen at approximately 10 am.
Aspirin Last
Crossover period Aspirin Last: Subjects will receive acetaminophen at approximately 8 am followed by 81 mg aspirin at approximately 10 am.
Acetaminophen 1000 mg/d
Subjects will receive a daily oral dose of 1000 mg acetaminophen for six days each administered at 8 AM.
Acetaminophen 4000 mg/d
Crossover period Acetaminophen 4000 mg/d: Acetaminophen (1000 mg p.o.) orally at 8 AM, 2 PM, 8 PM and 2 AM for 3 days. The last dose will be administered on day four at 8 AM.
Ibuprofen 800 mg/d
Crossover period Ibuprofen 800 mg/d: Ibuprofen (200 mg) orally at at 8 AM, 2 PM, 8 PM and 2 AM for 3 days. The last dose will be administered on day four at 8 AM.
Hospital of The University of Pennsylvania, Philadelphia
University of Pennsylvania
OTHER