Study of Gemcitabine and Cisplatin With or Without Cetuximab in Urothelial Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

89

Participants

Timeline

Start Date

March 31, 2008

Primary Completion Date

April 30, 2014

Study Completion Date

June 30, 2015

Conditions
Bladder Cancer
Interventions
DRUG

Gemcitabine,

Gemcitabine will be administered intravenously at a dose of 1000 mg/m2 on Days 1, 8 and 15 of cycle. One treatment cycle is 28 days.

DRUG

Cisplatin

Cisplatin will be administered intravenously at a dose of 70 mg/m2 per institutional standards on Day 1 of each cycle.

DRUG

Cetuximab

Cetuximab will be administered intravenously at a dose of 500 mg/m2 on Days 1 and 15 of each cycle. One treatment cycle is 28 days.

Trial Locations (14)

21231

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore

37232

Vanderbilt-Ingram Cancer Center, Nashville

48109

University of Michigan, Ann Arbor

48201

Wayne State University/Karmanos Cancer Institute, Detroit

60611

Robert H. Lurie Comprehensive Cancer Center, Center of Northwestern University, Chicago

84112

University of Utah Huntsman Cancer Institute, Salt Lake City

90033

Kenneth J. Norris Jr. Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles

91010

City of Hope Cancer Center, Duarte

94305

Stanford University, Stanford

98109

University of Washington, Seattle

02118

Boston Medical Center, Boston

01805

Lahey Clinic, Burlington

14263-0001

Roswell Park Cancer Institute, Buffalo

77030-3721

University of Texas MD Anderson Cancer Center, Houston

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

National Comprehensive Cancer Network

NETWORK

collaborator

Bristol-Myers Squibb

INDUSTRY

collaborator

Eli Lilly and Company

INDUSTRY

lead

University of Michigan Rogel Cancer Center

OTHER