Effectiveness of Deep Brain Stimulation for Treating People With Treatment Resistant Obsessive-Compulsive Disorder

PHASE4Active, not recruitingINTERVENTIONAL
Enrollment

27

Participants

Timeline

Start Date

March 31, 2008

Primary Completion Date

May 24, 2018

Study Completion Date

December 1, 2024

Conditions
Obsessive-Compulsive Disorder
Interventions
DEVICE

Active DBS

In DBS, thin wires are used to carry electric current to the parts of the brain involved in OCD symptoms. These wires are implanted surgically and are attached to battery operated stimulators usually implanted in the chest. The study doctor will adjust the settings of the electrical stimulation to optimize treatment for each participant. After a post-operative rest, participants will receive immediate DBS treatment throughout.

DEVICE

Sham DBS

In DBS, thin wires are used to carry electric current to the parts of the brain involved in OCD symptoms. These wires are implanted surgically and are attached to battery operated stimulators usually implanted in the chest. The study doctor will mimic adjusting the settings of the electrical stimulation. After a post-operative rest, participants will receive DBS treatment after a delay of several months. Afterwards, all participants will receive open-label long-term DBS.

Trial Locations (9)

20037

George Washington University Hospital, Washington D.C.

27157

Wake Forest Baptist Medical Center, Winston-Salem

32610

University of Florida, Gainesville

44195

The Cleveland Clinic, Cleveland

55905

Mayo Clinic, Rochester

60637

University of Chicago, Chicago

94063

Kaiser Permanente Redwood City Hospital, Redwood City

02114

Massachusetts General Hospital, Boston

02906

Butler Hospital, Providence

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

National Institute of Mental Health (NIMH)

NIH

lead

Butler Hospital

OTHER