27
Participants
Start Date
March 31, 2008
Primary Completion Date
May 24, 2018
Study Completion Date
December 1, 2024
Active DBS
In DBS, thin wires are used to carry electric current to the parts of the brain involved in OCD symptoms. These wires are implanted surgically and are attached to battery operated stimulators usually implanted in the chest. The study doctor will adjust the settings of the electrical stimulation to optimize treatment for each participant. After a post-operative rest, participants will receive immediate DBS treatment throughout.
Sham DBS
In DBS, thin wires are used to carry electric current to the parts of the brain involved in OCD symptoms. These wires are implanted surgically and are attached to battery operated stimulators usually implanted in the chest. The study doctor will mimic adjusting the settings of the electrical stimulation. After a post-operative rest, participants will receive DBS treatment after a delay of several months. Afterwards, all participants will receive open-label long-term DBS.
George Washington University Hospital, Washington D.C.
Wake Forest Baptist Medical Center, Winston-Salem
University of Florida, Gainesville
The Cleveland Clinic, Cleveland
Mayo Clinic, Rochester
University of Chicago, Chicago
Kaiser Permanente Redwood City Hospital, Redwood City
Massachusetts General Hospital, Boston
Butler Hospital, Providence
Lead Sponsor
National Institute of Mental Health (NIMH)
NIH
Butler Hospital
OTHER