1,671
Participants
Start Date
January 31, 2003
Study Completion Date
January 31, 2004
Parecoxib Sodium/Valdecoxib
Parecoxib sodium 40 mg intravenous (IV) on the day after surgery (Day 1) following recovery from anesthesia, contingent on an acceptable postoperative status, verification of baseline eligibility, and lack of perioperative complications. A second dose of parecoxib sodium 20 mg IV was administered on Day 1. On the day following surgery, patients received parecoxib 20 mg IV at 8 am and each subsequent dose was administered at 12-hour intervals. After receiving at least 6 doses of IV parecoxib sodium, patients were transitioned to oral valdecoxib 20 mg taken at 12-hour intervals until the total treatment duration of 10 days had been completed.
Placebo/Valdecoxib
Patients received placebo matched to parecoxib sodium 40 mg IV on Day 1 following recovery from anesthesia, contingent on an acceptable postoperative status, verification of baseline eligibility, and lack of perioperative complications. A second dose of placebo matched to parecoxib sodium 20 mg IV was administered on Day 1. On the day following surgery, patients received placebo matched to parecoxib sodium 20 mg IV at 8 am and each subsequent dose was administered at 12-hour intervals. After receiving at least 6 doses of IV placebo, patients were transitioned to oral valdecoxib 20 mg taken at 12-hour intervals until the total treatment duration of 10 days had been completed.
Placebo/Placebo
Patients received placebo matched to parecoxib sodium 40 mg IV on Day 1 following recovery from anesthesia, contingent on an acceptable postoperative status, verification of baseline eligibility, and lack of perioperative complications. A second dose of placebo matched to parecoxib sodium 20 mg IV was administered on Day 1. On the day following surgery, patients received placebo matched to parecoxib sodium 20 mg IV at 8 am and each subsequent dose was administered at 12-hour intervals. After receiving at least 6 doses of IV placebo, patients were transitioned to oral placebo matched to valdecoxib 20 mg taken at 12-hour intervals until the total treatment duration of 10 days had been completed.
Pfizer Investigational Site, Brussels
Pfizer Investigational Site, Brussels
Pfizer Investigational Site, Buenos Aires
Pfizer Investigational Site, Geneva
Pfizer Investigational Site, Buenos Aires
Pfizer Investigational Site, Morón
Pfizer Investigational Site, Timișoara
Pfizer Investigational Site, Feiring
Pfizer Investigational Site, Copenhagen
Pfizer Investigational Site, Edegem
Pfizer Investigational Site, Bern
Pfizer Investigational Site, Clayton
Pfizer Investigational Site, Cluj-Napoca
Pfizer Investigational Site, Genk
Pfizer Investigational Site, Auchenflower
Pfizer Investigational Site, Odense C
Pfizer Investigational Site, Ashford
Pfizer Investigational Site, Bucharest
Pfizer Investigational Site, Parow
Pfizer Investigational Site, Graz
Pfizer Investigational Site, Bloemfontein
Pfizer Investigational Site, New York
Pfizer Investigational Site, Mexico City
Pfizer Investigational Site, Mexico City
Pfizer Investigational Site, Prague
Pfizer Investigational Site, Rochester
Pfizer Investigational Site, Pittsburgh
Pfizer Investigational Site, Pittsburgh
Pfizer Investigational Site, Prague
Pfizer Investigational Site, Altoona
Pfizer Investigational Site, Washington D.C.
Pfizer Investigational Site, Milan
Pfizer Investigational Site, Hamburg
Pfizer Investigational Site, Takoma Park
Pfizer Investigational Site, Towson
Pfizer Investigational Site, Baltimore
Pfizer Investigational Site, Salisbury
Pfizer Investigational Site, Annandale
Pfizer Investigational Site, Falls Church
Pfizer Investigational Site, Fredericksburg
Pfizer Investigational Site, Norfolk
Pfizer Investigational Site, Kiel
Pfizer Investigational Site, Pavia
Pfizer Investigational Site, Madrid
Pfizer Investigational Site, Charleston
Pfizer Investigational Site, Charleston
Pfizer Investigational Site, Charleston
Pfizer Investigational Site, Charleston
Pfizer Investigational Site, Atlanta
Pfizer Investigational Site, Augusta
Pfizer Investigational Site, Jacksonville
Pfizer Investigational Site, Pensacola
Pfizer Investigational Site, Pensacola
Pfizer Investigational Site, Melbourne
Pfizer Investigational Site, Brandon
Pfizer Investigational Site, Tampa
Pfizer Investigational Site, St. Petersburg
Pfizer Investigational Site, Clearwater
Pfizer Investigational Site, Kassel
Pfizer Investigational Site, Sarasota
Pfizer Investigational Site, Haifa
Pfizer Investigational Site, Hudson
Pfizer Investigational Site, Giessen
Pfizer Investigational Site, Fairhope
Pfizer Investigational Site, Mobile
Pfizer Investigational Site, Mobile
Pfizer Investigational Site, Mobile
Pfizer Investigational Site, Mobile
Pfizer Investigational Site, Göttingen
Pfizer Investigational Site, Memphis
Pfizer Investigational Site, Sandusky
Pfizer Investigational Site, Cincinnati
Pfizer Investigational Site, Cincinnati
Pfizer Investigational Site, Dayton
Pfizer Investigational Site, Dayton
Pfizer Investigational Site, Valencia
Pfizer Investigational Site, Fort Wayne
Pfizer Investigational Site, Royal Oak
Pfizer Investigational Site, Münster
Pfizer Investigational Site, Livonia
Pfizer Investigational Site, Detroit
Pfizer Investigational Site, Petah Tikva
Pfizer Investigational Site, Muskegon
Pfizer Investigational Site, Florence
Pfizer Investigational Site, Aachen
Pfizer Investigational Site, Iowa City
Pfizer Investigational Site, Tel Litwinsky
Pfizer Investigational Site, Bonn
Pfizer Investigational Site, Elkhorn
Pfizer Investigational Site, Milwaukee
Pfizer Investigational Site, Madison
Pfizer Investigational Site, Pisa
Pfizer Investigational Site, Holon
Pfizer Investigational Site, Kansas City
Pfizer Investigational Site, Heidelberg
Pfizer Investigational Site, Kuopio
Pfizer Investigational Site, Bucharest
Pfizer Investigational Site, Fayetteville
Pfizer Investigational Site, Springdale
Pfizer Investigational Site, Oklahoma City
Pfizer Investigational Site, Tulsa
Pfizer Investigational Site, Irving
Pfizer Investigational Site, Fort Worth
Pfizer Investigational Site, Houston
Pfizer Investigational Site, Amarillo
Pfizer Investigational Site, Fort Collins
Pfizer Investigational Site, Fort Collins
Pfizer Investigational Site, München
Pfizer Investigational Site, Tucson
Pfizer Investigational Site, Los Angeles
Pfizer Investigational Site, Jerusalem
Pfizer Investigational Site, Jerusalem
Pfizer Investigational Site, Jerusalem
Pfizer Investigational Site, Anaheim
Pfizer Investigational Site, Anaheim
Pfizer Investigational Site, Orange
Pfizer Investigational Site, San Francisco
Pfizer Investigational Site, Stanford
Pfizer Investigational Site, Santa Rosa
Pfizer Investigational Site, Santa Rosa
Pfizer Investigational Site, Sacramento
Pfizer Investigational Site, Sacramento
Pfizer Investigational Site, Portland
Pfizer Investigational Site, Tacoma
Pfizer Investigational Site, Moscow
Pfizer Investigational Site, Moscow
Pfizer Investigational Site, Singapore
Pfizer Investigational Site, Bucharest
Pfizer Investigational Site, Los Angeles
Pfizer Investigational Site, San Francisco
Pfizer Investigational Site, San Francisco
Pfizer Investigational Site, New Haven
Pfizer Investigational Site, New Haven
Pfizer Investigational Site, Melbourne
Pfizer Investigational Site, Boston
Pfizer Investigational Site, Cambridge
Pfizer Investigational Site, Fort Worth
Pfizer Investigational Site, Burlington
Pfizer Investigational Site, Buenos Aires
Pfizer Investigational Site, Liège
Pfizer Investigational Site, Edmonton
Pfizer Investigational Site, Vancouver
Pfizer Investigational Site, Vancouver
Pfizer Investigational Site, Winnipeg
Pfizer Investigational Site, Halifax
Pfizer Investigational Site, Kingston
Pfizer Investigational Site, Kingston
Pfizer Investigational Site, London
Pfizer Investigational Site, Toronto
Pfizer Investigational Site, Toronto
Pfizer Investigational Site, Fleurimont
Pfizer Investigational Site, Montreal
Pfizer Investigational Site, Montreal
Pfizer Investigational Site, Regina
Pfizer Investigational Site, Saskatoon
Pfizer Investigational Site, Bogota
Pfizer Investigational Site, Floridablanca
Pfizer Investigational Site, Santiago de Cali
Pfizer Investigational Site, Bogotá
Pfizer Investigational Site, Kuopio
Pfizer Investigational Site, Oulu
Pfizer Investigational Site, Dublin
Pfizer Investigational Site, Beersheba
Pfizer Investigational Site, Haifa
Pfizer Investigational Site, Ramat Gan
Pfizer Investigational Site, Rehovot
Pfizer Investigational Site, Tel Aviv
Pfizer Investigational Site, Bloemfontein
Pfizer Investigational Site, Johannesburg
Pfizer Investigational Site, Pretoria
Pfizer Investigational Site, Durban
Pfizer Investigational Site, Liverpool
Pfizer Investigational Site, České Budějovice
Pfizer Investigational Site, Prague
Pfizer Investigational Site, Prague
Pfizer Investigational Site, Prague
Pfizer Investigational Site, Turku
Pfizer Investigational Site, Mexico City
Pfizer Investigational Site, Mexico City
Pfizer Investigational Site, Mexico City
Pfizer Investigational Site, Breda
Pfizer Investigational Site, Eindhoven
Pfizer Investigational Site, Zwolle
Pfizer Investigational Site, Bialystok
Pfizer Investigational Site, Krakow
Pfizer Investigational Site, Poznan
Pfizer Investigational Site, Szczecin
Pfizer Investigational Site, Warsaw
Pfizer Investigational Site, Bratislava
Pfizer Investigational Site, Košice
Pfizer Investigational Site, Pretoria
Pfizer Investigational Site, Pretoria
Pfizer Investigational Site, Pretoria
Pfizer Investigational Site, Les Marais
Pfizer Investigational Site, Pretoria
Pfizer Investigational Site, Pretoria
Pfizer Investigational Site, Barcelona
Pfizer Investigational Site, Barcelona
Pfizer Investigational Site, Örebro
Pfizer Investigational Site, Stockholm
Pfizer Investigational Site, Uppsala
Pfizer Investigational Site, Edinburgh
Pfizer Investigational Site, London
Pfizer Investigational Site, London
Pfizer Investigational Site, Middlesbrough
Pfizer Investigational Site, Oxford
Lead Sponsor
Pfizer
INDUSTRY