18
Participants
Start Date
July 31, 1999
Primary Completion Date
July 31, 2008
Study Completion Date
July 31, 2008
MDD diagnosis and Estrogen treatment
Treatment for major depressive disorder occurring in the context of the menopause while participating in brain imaging sessions pre and post treatment. Women receiving treatment for depression will be compared to normal controls receiving estrogen only for physical symptoms of menopause.
MDD diagnosis and Fluoxetine treatment
Menopausal women between the ages of 40-70 diagnosed with Major Depressive Disorder receiving treatment with fluoxetine alone.
MDD diagnosis with both Estrogen and Fluoxetine treatment
Menopausal women between the ages of 40-70 diagnosed with Major Depressive Disorder receiving treatment with estrogen and fluoxetine combined.
No depression and estrogen treatment
Control participants with no MDD diagnosis received estrogen only for the treatment of physical symptoms of menopause.
Yale University, New Haven
University of Pennsylvania
OTHER