Safety and Immunogenicity of Chiron's Investigational H. Pylori Vaccine in Healthy Adults

PHASE1CompletedINTERVENTIONAL
Enrollment

113

Participants

Timeline

Start Date

February 28, 2001

Primary Completion Date

December 31, 2001

Study Completion Date

April 30, 2002

Conditions
Helicobacter PyloriGastritisGastric CancerGastroduodenal UlcersLymphoma
Interventions
BIOLOGICAL

helicobacter pylori vaccine

Experimental H. pylori vaccine including NAP, CagA and VacA antigens (abbreviated HP3), 10 micrograms of each antigen, 0,1,2 month schedule (alum control was administered at 4 months), administered intramuscularly

BIOLOGICAL

helicobacter pylori vaccine

Seven subjects, experimental H. pylori vaccine including NAP, CagA and VacA antigens (abbreviated HP3), 25 micrograms of each antigen, 0,1,2 month schedule (alum control was administered at 4 months), administered intramuscularly

BIOLOGICAL

helicobacter pylori vaccine

Seven subjects, experimental H. pylori vaccine including NAP, CagA and VacA antigens (abbreviated HP3), 10 micrograms of each antigen, 0,1,4 month schedule (alum control was administered at 2 months), administered intramuscularly

BIOLOGICAL

helicobacter pylori vaccine

Eight subjects, experimental H. pylori vaccine including NAP, CagA and VacA antigens (abbreviated HP3), 25 micrograms of each antigen, 0,1,4 month schedule (alum control was administered at 2 months), administered intramuscularly

BIOLOGICAL

Placebo

Nine subjects, alum control (placebo comparator), 0,1,2,4 month schedule (served as control for arms 1-4), administered intramuscularly

BIOLOGICAL

helicobacter pylori vaccine

Nine subjects, experimental H. pylori vaccine including NAP, CagA and VacA antigens (abbreviated HP3), 10 micrograms of each antigen, 0,1,2 week schedule, administered intramuscularly

BIOLOGICAL

helicobacter pylori vaccine

Ten subjects, experimental H. pylori vaccine including NAP, CagA and VacA antigens (abbreviated HP3), 25 micrograms of each antigen, 0,1,2 week schedule, administered intramuscularly

Trial Locations (1)

10117

Universitaetsklinikum Charité, Berlin

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Novartis Vaccines

INDUSTRY

NCT00613665 - Safety and Immunogenicity of Chiron's Investigational H. Pylori Vaccine in Healthy Adults | Biotech Hunter | Biotech Hunter