Combination Chemotherapy Based on Risk of Relapse in Treating Young Patients With Acute Lymphoblastic Leukemia

10 mg/sqm/day from for 21 days

native E-coli Asparaginase 5,000 IU/sqm x 8 doses

native E-Coli Asparaginase 10,000 IU/sqm x 4 doses

1,000 mg/sqm i.v. 2 doses in Induction phase 1000 mg/sqm i.v. 1 dose in Protocoll II 500 mg/sqm i.v. 1 dose in protocol III

75 mg/sqm i.v.or s.c. 4 doses/week for 4 weeks in Induction phase 75 mg/sqm i.v.or s.c. 4 doses/week for 2 weeks in Protocol II and III

30 mg/sqm i.v. 4 doses in Induction phase

30 mg/sqm i.v. x 4 doses in Protocol II and III

100 mg/sqm i.v. for 3 doses in HR block 3

800 mg/sqm i.v.q12h x 5 in HR block 2

60 mg/sqm p.o. c 28 days in Induction phase 60 mg/sqm p.o. x 56 days in Protocol M 50 mg/sqm daily in Maintenance phase

by age i.t. in Induction/Protocol M/Protocol II/Protocol III/HR Blocks and maintenance

60 mg/sqm daily p.o. for 28 days then tapered in Induction phase

60 mg/sqm p.o. x 14 days in Protocol II and Protocol III

1.5 mg/sqm i.v. x 4 doses in Induction phase and Protocol II 1.5 mg/sqm i.v. x 2 doses in Protocol III and HR block 1

3 mg/sqm i.v. x 2 doses in HR block 2