Effect of Valproic Acid Concentration on Photic Response

PHASE4CompletedINTERVENTIONAL
Enrollment

13

Participants

Timeline

Start Date

December 31, 2007

Primary Completion Date

December 31, 2008

Study Completion Date

December 31, 2008

Conditions
Photosensitive Epilepsy
Interventions
DRUG

Valproic Acid

The investigators will utilize intravenous sodium valproate at visit 3. Dosage will be individualized to each patient's body weight, age, and hepatic-enzyme-inducing status. Intravenous VPA dose predictions will be based upon population VPA pharmacokinetic parameters (Dutta 2003).

DRUG

Placebo

Each patient will have a placebo-infusion (with 0.9% NS or D5W) of 12-hour duration at visit 2.

Trial Locations (2)

37232

Vanderbilt University, Nashville

63017

The Comprehensive Epilepsy Care Center for Children & Adults, Chesterfield

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Abbott

INDUSTRY

lead

Vanderbilt University Medical Center

OTHER