Sorafenib/Erlotinib Versus Erlotinib Alone in Previously Treated Advanced Non-Small-Cell Lung Cancer (NSCLC)

PHASE2CompletedINTERVENTIONAL
Enrollment

166

Participants

Timeline

Start Date

February 29, 2008

Primary Completion Date

February 28, 2009

Study Completion Date

February 28, 2009

Conditions
Non-Small Cell Lung Cancer
Interventions
DRUG

Erlotinib + Sorafenib

Patients who are randomized to Cohort A will take sorafenib 400 mg (2 x 200-mg tablets) orally twice a day, and erlotinib 150 mg orally once a day.

DRUG

Erlotinib + Placebo

Patients who are randomized to Cohort B will take erlotinib 150 mg orally once a day and placebo orally twice a day.

Trial Locations (16)

20817

Center for Cancer and Blood Disorders, Bethesda

23235

Virginia Cancer Institute, Richmond

28801

Cancer Care of Western North Carolina, Asheville

29210

South Carolina Oncology Associates, PA, Columbia

30060

Wellstar Cancer Research, Marietta

30501

Northeast Georgia Medical Center, Gainesville

33901

Florida Cancer Specialists, Fort Myers

37023

Tennessee Oncology, PLLC, Nashville

37404

Chattanooga Oncology Hematology Associates, Chattanooga

38017

Family Cancer Center, Collierville

43219

Mid Ohio Oncology/Hematology, Inc./ The Mark H. Zangmeister Center, Columbus

45242

Oncology Hematology Care, Cincinnati

49503

Grand Rapids Clinical Oncology Program, Grand Rapids

66210

Kansas City Cancer Centers, Overland Park

68114

Methodist Cancer Center, Omaha

78463

Coastal Bend Cancer Center, Corpus Christi

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Bayer

INDUSTRY

lead

SCRI Development Innovations, LLC

OTHER