Radiosensitization With Celecoxib and Chemoradiation for Head and Neck Cancer

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

September 30, 2002

Primary Completion Date

December 31, 2007

Study Completion Date

March 31, 2012

Conditions
Cancer
Interventions
DRUG

celecoxib

400mg bid starting 1 week before radiotherapy and taken through radiotherapy.

DRUG

Carboplatin

IV, AUC 2.0, weekly for weeks 1 through 7

DRUG

Paclitaxel

IV 30 mg/m2, weekly for weeks 1 through 7

RADIATION

Radiation Therapy

70.2Gy, at 1.8Gy qd, Monday through Friday

Trial Locations (1)

35249

University of Alabama at Birmingham, Birmingham

Sponsors
All Listed Sponsors
collaborator

Bristol-Myers Squibb

INDUSTRY

collaborator

Pharmacia

INDUSTRY

lead

University of Alabama at Birmingham

OTHER