"UARK 89-001 Phase II Study of Intensive TOTAL THERAPY For Untreated or Minimally Treated Patients With Multiple Myeloma"

3 Cycles (3rd cycle optional): Vincristine 0.5 mg/d d 1 - 4 CI Adriamycin 10 mg/m2/d d 1 - 4 CI Dexamethasone 40 mg/d d 1-4, 9-12, 17-20

"Approximately 5-6 weeks after VAD 2 or 3:~Cytoxan 1.2g/m2/d d 1 - 5 Mesna 3.6 g/m2 d 1"

Collection target = 10 x 10\^6 cells/kg

Approximately 5-6 weeks after high-dose cyclophosphamide Etoposide 100 mg/m2/d d 1 - 4 CI Cisplatin 25 mg/m2/d d 1 - 4 CI Ara C l g/m2 d 5 Dexamethasone 40 mg d 1-5

4-6 weeks after EDAP: Melphalan 100 mg/m2 days -1 and -2

4-6 months after Transplant 1: Melphalan 100 mg/m2 days -1 and -2

3 months after Transplant 2: Intron A 3 X 10\^6 units /m2 M-W-F subcutaneously until relapse