Preoperative Cisplatin and Bevacizumab in ER-, PR-, HER2 Negative Breast Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

51

Participants

Timeline

Start Date

September 30, 2007

Primary Completion Date

December 31, 2010

Study Completion Date

June 30, 2020

Conditions
Breast Cancer
Interventions
DRUG

cisplatin

Preoperatively: Given intravenously on day one of the treatment cycle (once every 3 weeks) for four cycles

DRUG

bevacizumab

Preoperatively: Given intravenously on day 1 of the treatment cycle (once every three weeks) for three cycles Postoperatively: Intravenously for four 2-week cycles (once every two weeks) and after the 8 weeks (study doctor will determine course of treatment) for an additional four 2-week cycles with or with out paclitaxel

DRUG

doxorubicin

Postoperative: Given intravenously for four 2-week cycles

DRUG

cyclophosphamide

Postoperative: Given intravenously for four two-week cycles

DRUG

paclitaxel

Postoperative: 8 weeks after postoperative chemotherapy regimen (study doctor will determine course of treatment) paclitaxel for four 2-week cycles (once every two weeks)

Trial Locations (3)

02114

Massachusetts General Hospital, Boston

02115

Beth Israel Deaconess Medical Center, Boston

Dana-Farber Cancer Institute, Boston

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Dana-Farber Cancer Institute

OTHER

collaborator

Beth Israel Deaconess Medical Center

OTHER

collaborator

Brigham and Women's Hospital

OTHER

collaborator

Genentech, Inc.

INDUSTRY

lead

Massachusetts General Hospital

OTHER