Safety and Efficacy of PF-04217329 in Patients With Glaucoma or Elevated Eye Pressure.

PHASE2CompletedINTERVENTIONAL
Enrollment

318

Participants

Timeline

Start Date

December 11, 2007

Primary Completion Date

June 26, 2009

Study Completion Date

June 26, 2009

Conditions
Primary Open-Angle GlaucomaOcular Hypertension
Interventions
DRUG

PF-04217329 - Lowest Dose

1 drop of lowest dose PF-04217329, once a day, per dosed eye for duration of study.

DRUG

PF-04217329 - Low Dose

1 drop of low dose PF-04217329, once a day, per dosed eye for duration of study.

DRUG

PF-04217329 - Middle Dose

1 drop of middle dose PF-04217329, once a day, per dosed eye for duration of study.

DRUG

PF-04217329 - High Middle Dose

1 drop of high middle dose PF-04217329, once a day, per dosed eye for duration of study.

DRUG

PF-04217329 - High Dose

1 drop of high dose PF-04217329, once a day, per dosed eye for duration of study.

DRUG

PF-4217329 - Highest Dose

1 drop of highest dose PF-04217329, once a day, per dosed eye for duration of study.

DRUG

PF-04217329 - Vehicle

1 drop of PF-04217329 vehicle, once a day, per dosed eye for duration of study.

DRUG

Latanoprost Vehicle

1 drop of latanoprost vehicle, once a day, per dosed eye for duration of study.

DRUG

PF-04217329 - Low Dose

Five minutes after latanoprost vehicle, 1 drop of low dose PF-04217329, once a day, per dosed eye for duration of study.

DRUG

Latanoprost Vehicle

1 drop of latanoprost vehicle, once a day, per dosed eye for duration of study.

DRUG

PF-04217329 - Middle Dose

Five minutes after latanoprost vehicle, 1 drop of middle dose PF-04217329, once a day, per dosed eye for duration of study.

DRUG

Latanoprost Vehicle

1 drop of latanoprost vehicle, once a day, per dosed eye for duration of study.

DRUG

PF-04217329 - High Dose

Five minutes after latanoprost vehicle, 1 drop of high dose PF-04217329, once a day, per dosed eye for duration of study.

DRUG

Latanoprost 0.005%

1 drop of latanoprost 0.005%, once a day, per dosed eye for duration of study.

DRUG

PF-04217329 - Low Dose

Five minutes after latanoprost 0.005%, 1 drop of low dose PF-04217329, once a day, per dosed eye for duration of study.

DRUG

Latanoprost 0.005%

1 drop of latanoprost 0.005%, once a day, per dosed eye for duration of study.

DRUG

PF-04217329 - Middle Dose

Five minutes after latanoprost 0.005%, 1 drop middle dose PF-04217329, once a day, per dosed eye for duration of study.

DRUG

Latanoprost 0.005%

1 drop of latanoprost 0.005%, once a day, per dosed eye for duration of study.

DRUG

PF-04217329 - High Dose

Five minutes after latanoprost 0.005%, 1 drop high dose PF-04217329, once a day, per dosed eye for duration of study.

DRUG

Latanoprost 0.005%

1 drop of latanoprost 0.005%, once a day, per dosed eye for duration of study.

DRUG

PF-04217329 - Vehicle

Five minutes after latanoprost 0.005%, 1 drop of PF-04217329 vehicle, once a day, per dosed eye for duration of study.

Trial Locations (23)

14618

Rochester Ophthalmological Group, PC, Rochester

19007

Glaucoma Care Center at Century Eye Care, Bristol

19107

Wills Eye Institute, Philadelphia

27262

Cornerstone Eye Care, High Point

28210

Charlotte Eye Ear Nose and Throat Associates, PA, Charlotte

30260

Eye Care Centers Management, Inc., Morrow

30339

Coastal Research Associates,LLC, Atlanta

30342

Omni Eye Services of Atlanta, Atlanta

32114

Atlantic Institute of Clinical Research, Daytona Beach

Florida Health Care Plans, Daytona Beach

32174

International Eye Associates, PA, Ormond Beach

33901

Eye Associates of Fort Myers, Fort Myers

38119

Total Eye Care, PA, Memphis

40217

Taustine Eye Center, Louisville

47710

The Eye Group of Southern Indiana, Evansville

74104

Mark J. Weiss, MD. Inc., Tulsa

78746

Texan Eye Care, PA, Austin

78756

Eye Physicians of Austin, Austin

90701

Sall Research Medical Center, Artesia

92064

Centre For Health Care, Poway

92663

Eye Research Foundation, Newport Beach

94954

North Bay Eye Associates, Inc., Petaluma

29414-5893

Bluestein Custom Vision, Charleston

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY