Evaluating The Efficacy And Safety Of Donepezil Hydrochloride (HCl) (Aricept) In Treating Cognitive Dysfunction Exhibited By Children With Down Syndrome

PHASE2CompletedINTERVENTIONAL
Enrollment

129

Participants

Timeline

Start Date

November 16, 2007

Primary Completion Date

September 5, 2008

Study Completion Date

September 5, 2008

Conditions
Down Syndrome
Interventions
DRUG

Donepezil HCl

Blinded donepezil 2.5 milligram per day (mg/day) (2.5 milliliter per day \[mL/day\]) orally for participants with body weight (BW) 20 and less than (\<) 25 kilogram (kg), 5 mg/day (5 mL/day) orally for participants with BW 25 to \<50 kg, and 10 mg/day (10 mL/day) orally for participants with BW greater than or equal to (\>=) 50 kg liquid formulation (1 milligram per 1 milliliter \[1 mg/1 mL\]) (titrated to 0.1 to 0.2 milligram per kilogram per day \[mg/kg/day\] based on BW).

DRUG

Placebo

Liquid formulation matched to active treatment for oral administration.

Trial Locations (31)

27710

Duke University Medical Center, Durham

29425

Medical University of South Carolina, Division of Genetics and Developmental and Behavioral Pediatrics, Charleston

30342

Child Neurology Associates, PC, Atlanta

33155

Community Research Foundation, Miami

Miami Children's Hospital, Brain Institute, Miami

33407

Lazlo J. Mate, MD, West Palm Beach

33709

Meridien Research, St. Petersburg

33912

Neuropsychiatric Research Center of South West Florida, Fort Myers

43606

Valko and Associates, Toledo

44109

Metrohealth Medical Center, Division of Psychiatry, Cleveland

46077

Medical Genetics and Neuro Development Center, Zionsville

48503

Hurley Medical Center, Flint

49503

Saint Mayr's Health Care, Grand Rapids

63110

Washington University School of Medicine, Division of Genetics and Genomic Medicine, St Louis

68504

Midwest Children's Health Research Institute, LLC, Lincoln

72205

Clinical Study Centers, L.L.C., Little Rock

77030

Down Syndrome Clinic of Houston, Houston

78258

Alamo City Clinical Research, LLC, San Antonio

Road Runner Research, San Antonio

80214

Rocky Mountain Pediatrics, Lakewood

85016

Phoenix Children's Hospital, Phoenix

90048

Neufeld Medical Group, Inc., Los Angeles

92123

UCSD Pediatric Pharmacology Research Unit, San Diego

92868

University of California, Irvine Medical Center, Department of Pediatrics, Orange

94609

Children's Hospital and Research Center at Oakland, Oakland

98004

Northwest Clinical Research Center, Bellevue

33155-3009

Miami Children's Hospital, Clinical Research Center, Miami

55101-2529

Regions Hospital, Saint Paul

08043

Clinical Research Center of New Jersey, Voorhees Township

74104-5428

Tulsa Clinical Research LLC, Tulsa

37232-9225

Vanderbilt Children's Hospital, Nashville

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Pfizer

INDUSTRY

lead

Eisai Inc.

INDUSTRY