A Safety and Efficacy Study of Naltrexone SR/Bupropion SR in Overweight and Obese Subjects

PHASE3CompletedINTERVENTIONAL
Enrollment

1,496

Participants

Timeline

Start Date

December 31, 2007

Primary Completion Date

June 30, 2009

Study Completion Date

June 30, 2009

Conditions
ObesityOverweight
Interventions
DRUG

Naltrexone SR 32 mg/bupropion SR 360 mg/day

DRUG

Placebo

BEHAVIORAL

Ancillary therapy

Ancillary therapy consisting of diet instruction, advice on behavior modification, and exercise counseling

Trial Locations (36)

10021

Comprehensive Weight Control Program, New York

10305

Behavioral Medical Research, Staten Island

13104

Central New York Clinical Research, Manlius

17822

Geisinger Medical Center, Danville

20037

George Washington University, Washington D.C.

28209

Metrolina Medical Research, Charlotte

29349

Mountain View Clinical Research, Greer

29464

Palmetto Medical Research, Mt. Pleasant

30281

Clinical Research Atlanta, Stockbridge

30328

Comprehensive NeuroScience, Inc, Atlanta

34684

Suncoast Clinical Research, Palm Harbor

37203

Clinical Research Associates, Inc., Nashville

42431

Trover Center for Clinical Studies, Madisonville

45242

Patient Priority, Cincinnati

45429

Wells Institute For Health Awareness, Kettering

46383

Northwest Indiana Center for Clinical Research, Valparaiso

48864

Summit Research Network, Inc., Okemos

55430

Twin Cities Clinical Research, Brooklyn Center

63141

Mercy Health Research, St Louis

Radiant Research, Inc., St Louis

71913

HealthStar Research, Hot Springs

75230

The Cooper Institute, Dallas

80220

Center for Human Nutrition University of Colorado Health Sciences Center, Denver

85016

Lovelace Scientific Resources, Phoenix

85050

HOPE Research Institute, Phoenix

87108

Lovelace Scientific Resources, Albuquerque

89104

Clinical Research Center of Nevada, Las Vegas

92660

Pharmacology Research Institute, Newport Beach

93710

Sierra Medical Research, Fresno

97205

The Portland Clinic, Portland

98104

Summit Research Network, Inc., Seattle

98608

Northern California Research, Carmichael

06708

Chase Medical Research, LLC, Waterbury

02118

Nutrition and Weight Mangement Center Boston Medical Center, Boston

01757

Milford Emergency Associates, Inc, Milford

03820

Endocrinology & Diabetes Consultants, Dover

Sponsors
All Listed Sponsors
lead

Orexigen Therapeutics, Inc

INDUSTRY