Dasatinib in Combination With Zoledronic Acid for the Treatment of Breast Cancer With Bone Metastasis

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

31

Participants

Timeline

Start Date

November 1, 2007

Primary Completion Date

November 17, 2020

Study Completion Date

November 17, 2020

Conditions
Breast CancerBone Metastases
Interventions
DRUG

Dasatinib

"Phase I: First Cohort = 100 mg PO Daily x 28 days; Next Cohort = Dose Expansion or Reduction Based on Dose Limiting Toxicity (DLT) in Initial Cohort.~Phase II: Recommended Phase II Dose (RP2D) as determined with Phase I."

DRUG

Zoledronic Acid

"Phase I: First Cohort = 4 mg IV Over 15 min. every 4 Weeks; Next Cohort = Dose Expansion or Reduction Based on Dose Limiting Toxicity (DLT) in Initial Cohort.~Phase II: Recommended Phase II Dose (RP2D) as determined with Phase I."

Trial Locations (3)

27708

Duke University, Durham

60637

University of Chicago, Chicago

77030

University of Texas MD Anderson Cancer Center, Houston

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Bristol-Myers Squibb

INDUSTRY

lead

M.D. Anderson Cancer Center

OTHER

NCT00566618 - Dasatinib in Combination With Zoledronic Acid for the Treatment of Breast Cancer With Bone Metastasis | Biotech Hunter | Biotech Hunter