Dasatinib in Combination With Revlimid (and Dexamethasone)

PHASE1CompletedINTERVENTIONAL
Enrollment

35

Participants

Timeline

Start Date

May 31, 2008

Primary Completion Date

October 31, 2011

Study Completion Date

November 30, 2012

Conditions
Multiple Myeloma
Interventions
DRUG

Dasatinib, 70 mg + Lenalidomide, 15 mg + Dexamethasone, 40 mg

Participants received dasatinib, 70 mg once daily (QD), for 28 days plus lenalidomide, 15 mg QD, for 21 days plus dexamethasone, 40 mg QD, weekly on Days 1, 8, 15, and 22.

DRUG

Dasatinib, 70 mg + Lenalidomide, 20 mg + Dexamethasone, 40 mg

Participants received dasatinib, 70 mg QD, for 28 days plus lenalidomide, 20 mg QD, for 21 days, plus dexamethasone, 40 mg QD, weekly on Days 1, 8, 15, and 22.

DRUG

Dasatinib, 100 mg + Lenalidomide, 20 mg + Dexamethasone, 40 mg

Participants received dasatinib, 100 mg QD, for 28 days, plus lenalidomide, 20 mg QD, for 21 days, plus dexamethasone, 40 mg QD, weekly on Days 1, 8, 15, and 22.

DRUG

Dasatinib, 100 mg + Lenalidomide, 25 mg + Dexamethasone, 40 mg

Participants received dasatinib, 100 mg QD, for 28 days, plus lenalidomide, 25 mg QD, for 21 days, plus dexamethasone, 40 mg QD, weekly on Days 1, 8, 15, and 22.

DRUG

Dasatinib, 140 mg + Lenalidomide, 25 mg + Dexamethasone, 40 mg

Participants received dasatinib, 140 mg QD, for 28 days, plus lenalidomide, 25 mg QD, for 21 days, plus dexamethasone, 40 mg QD, weekly on Days 1, 8, 15, and 22. Cohort includes 4 participants who received treatment during the dose-finding phase and 13 participants who received treatment in the dose-expansion phase.

Trial Locations (4)

3181

Local Institution, Prahran

31059

Local Institution, Toulouse

54511

Local Institution, Vandœuvre-lès-Nancy

85259

Mayo Clinic Arizona, Scottsdale

Sponsors
All Listed Sponsors
lead

Bristol-Myers Squibb

INDUSTRY