52
Participants
Start Date
June 30, 2004
Primary Completion Date
August 31, 2010
Study Completion Date
August 31, 2010
Minocycline
Minocycline IV BID x 7 days (first 10 patients 200 mg/dose, subsequent patients adjusted based on pharmacodynamic profiling to 800 mg loading dose, tapered 100 mg each dose to 400 mg then maintain at 400mg until day 7)
placebo
Normal saline 250cc via central line similar to minocycline arm administration protocol
SCPP augmentation
maintenance of spinal cord perfusion pressure at 75 mmHg with fluids and inotrope protocol
SCPP control
maintenance of Mean arterial pressure of \>65 mmHg with fluids and inotropes protocol without spinal cord perfusion pressure as target or guiding therapy
Foothills Medical Centre, Calgary
Paralyzed Veterans of America
OTHER
American Association of Neurological Surgeons
OTHER
Hotchkiss Brain Institute, University of Calgary
OTHER
University of Calgary
OTHER