91
Participants
Start Date
September 30, 2007
Primary Completion Date
May 31, 2008
Study Completion Date
May 31, 2008
Sorafenib + Paclitaxel + Carboplatin
Chemotherapy plus Multi Kinase Inhibitor: Sorafenib Group - Sorafenib (Nexavar, BAY43-9006), \[400 mg, (2 tablets x 200 mg each) orally, twice daily\] on Study Days 2-19 and paclitaxel (175 mg/m\^2, intravenous (IV), over 2.5 to 4 hours) and carboplatin (area under the curve (AUC) =5, IV for 15 to 60 minutes) on Study Day 1. The cycle duration will be 21 days.
Placebo + Paclitaxel + Carboplatin
Chemotherapy + Placebo: Placebo Group - Placebo (2 tablets twice daily, orally) on Study Days 2-19 and paclitaxel (175 mg/m\^2 IV, over 2.5 to 4 hours) and carboplatin (AUC=5 IV, for 15 to 60 minutes) on Study Day 1. The cycle duration will be 21 days
Taipei
Changhua
Bangkok
Beijing
Beijing
Beijing
New Delhi
Singapore
Singapore
Shanghai
Shanghai
Nanjing
Hangzhou
Mumbai
Chongqing
Guangzhou
Guangzhou
Shatin
Bangkok
Hangzhou
Gyeonggi-do
Seoul
Lead Sponsor
Bayer
INDUSTRY