WBRT & Erlotinib in Advanced NSCLC and Brain Metastases

PHASE2TerminatedINTERVENTIONAL
Enrollment

80

Participants

Timeline

Start Date

January 31, 2008

Primary Completion Date

November 30, 2010

Study Completion Date

November 30, 2010

Conditions
Lung CancerMetastatic Cancer
Interventions
DRUG

erlotinib hydrochloride

PO 100 mg daily during WBRT, increasing to 150mg daily after WBRT for up to 24 months

DRUG

placebo

WBRT plus matched placebo for the same schedule and duration as erlotinib hydrochloride

Trial Locations (7)

W6 8RF

Charing Cross Hospital, London

WIT 3AA

University College of London Hospitals, London

M20 4BX

Christie Hospital, Manchester

SP2 8BJ

Salisbury District Hospital, Salisbury

SO16 6YD

Southampton General Hospital, Southampton

LL18 5UJ

Glan Clwyd Hospital, Rhyl, Denbighshire

SA2 8QA

South West Wales Cancer Institute, Swansea

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Cancer Research UK

OTHER

collaborator

Roche Pharma AG

INDUSTRY

lead

University College, London

OTHER