Comparison of Ropivacaine and Levobupivacaine in High Thoracic Epidural Anesthesia

PHASE4CompletedINTERVENTIONAL
Enrollment

61

Participants

Timeline

Start Date

January 31, 2003

Study Completion Date

June 30, 2005

Conditions
Coronary Artery BypassEpidural Anesthesia
Interventions
DRUG

Ropivacaine

0.5% epidural bolus injection (0.1 mL kg-1) with sufentanil 2.5 µg mL-1 before general anesthesia induction, followed by 0.2% infusion (0.1 mL kg-1 h-1) with sufentanil 1 µg mL-1 throughout surgery; in ICU, 0.1% epidural infusion with sufentanil 1µg mL-1 at 0.1 mL kg-1 h-1 and the rate is modified following this protocol: on awakening (Ramsay 2) VAS on coughing is evaluated: if it is 4 the infusion rate is not changed, if the VAS is ≥ 4 the rate is increased by 2 mL h-1 after giving a 2 mL bolus and VAS is checked again 30 minutes later, if it is ≤ 4 the infusion rate is decreased by 2 mL h-1.

DRUG

Levobupivacaine

0.5% epidural bolus injection (0.1 mL kg-1) with sufentanil 2.5 µg mL-1 before general anesthesia induction, followed by 0.2% infusion (0.1 mL kg-1 h-1) with sufentanil 1 µg mL-1 throughout surgery; in ICU, 0.1% epidural infusion with sufentanil 1µg mL-1 at 0.1 mL kg-1 h-1 and the rate is modified following this protocol: on awakening (Ramsay 2) VAS on coughing is evaluated: if it is 4 the infusion rate is not changed, if the VAS is ≥ 4 the rate is increased by 2 mL h-1 after giving a 2 mL bolus and VAS is checked again 30 minutes later, if it is ≤ 4 the infusion rate is decreased by 2 mL h-1.

Trial Locations (1)

20138

Department of Anesthesia & ICU. IRCCS Centro Cardiologico Monzino, Milan

All Listed Sponsors
lead

Centro Cardiologico Monzino

OTHER

NCT00552864 - Comparison of Ropivacaine and Levobupivacaine in High Thoracic Epidural Anesthesia | Biotech Hunter | Biotech Hunter