Convenience, Tolerability, and Safety of Change in the Administration of Rivastigmine From Capsules to a Transdermal Patch in Patients With Mild to Moderate Alzheimer's Disease

PHASE4CompletedINTERVENTIONAL
Enrollment

142

Participants

Timeline

Start Date

September 30, 2007

Primary Completion Date

April 30, 2009

Study Completion Date

April 30, 2009

Conditions
Alzheimer's Disease
Interventions
DRUG

Rivastigmine patch (4.6 mg/day switch to 9.5 mg/day)

Rivastigmine administered transdermally via patches at increasing doses (1 patch/day of 4.6 mg for the first month, changing to 1 patch/day of 9.5 mg for the remaining two months).

DRUG

Rivastigmine patch (9.5 mg/day)

Rivastigmine administered transdermally via patches at a constant dose (9.5 mg/day for the 3 months of treatment).

DRUG

Rivastigmine capsules (6 mg to 12 mg/day)

Rivastigmine administered orally, following the same regime as prior to randomization (doses between 6 mg and 12 mg/day), which remained unchanged throughout the 3 months of treatment.

Trial Locations (1)

Unknown

Novartis Investigative Site, Barcelona

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Novartis

INDUSTRY