NCT00541138View on ClinicalTrials.gov

Tamoxifen, Carboplatin, and Topotecan in Treating Patients With CNS Metastases or Recurrent Brain or Spinal Cord Tumors

PHASE2CompletedINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

May 31, 2003

Primary Completion Date

October 31, 2007

Study Completion Date

October 31, 2007

Conditions
Brain and Central Nervous System TumorsMetastatic CancerUnspecified Adult Solid Tumor, Protocol Specific
Interventions
DRUG

carboplatin

CBDCA AUC=3

DRUG

tamoxifen citrate

Tamoxifen 100mg bid

DRUG

topotecan hydrochloride

Topotecan 0.75 g/m2/d

OTHER

pharmacological study

Start of tx, hours 24,28 and 72 during Topotecan infusion, and hours 1,2,4 and 6 after end of Topotecan infusion.

Trial Locations (1)

91010-3000

City of Hope Comprehensive Cancer Center, Duarte

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

City of Hope Medical Center

OTHER

NCT00541138 - Tamoxifen, Carboplatin, and Topotecan in Treating Patients With CNS Metastases or Recurrent Brain or Spinal Cord Tumors | Biotech Hunter | Biotech Hunter