Investigation of the Safety and Feasibility of AAV1/SERCA2a Gene Transfer in Patients With Chronic Heart Failure

PHASE2TerminatedINTERVENTIONAL
Enrollment

5

Participants

Timeline

Start Date

July 31, 2014

Primary Completion Date

September 30, 2015

Study Completion Date

September 30, 2015

Conditions
Chronic Heart FailurePatients That Have Received a Left Ventricular Assist Device
Interventions
GENETIC

AAV1/SERCA2a

AAV1/SERCA2a will be delivered by a percutaneous method in the catheter laboratory. Dose: 1x 10\^13 DRP (DNase resistant particles)

DRUG

Placebo

Placebo aliquots will be of the same composition as the investigational medicinal product with the absence of the active ingredient and will be visually indistinguishable from the medicinal product. Placebo is prepared and handled exactly as above in a blinded fashion.

Trial Locations (2)

CB23 3RE

Papworth Hospital, Cambridge

UB9 6JH

Harefield Hospital, Royal Brompton and Harefiled NHS Trust, Middlesex

Sponsors
All Listed Sponsors
collaborator

British Heart Foundation

OTHER

collaborator

Leducq Foundation

OTHER

collaborator

Celladon Corporation

INDUSTRY

lead

Imperial College London

OTHER

NCT00534703 - Investigation of the Safety and Feasibility of AAV1/SERCA2a Gene Transfer in Patients With Chronic Heart Failure | Biotech Hunter | Biotech Hunter