A Study of the Safety and Efficacy of Two Doses of Naltrexone SR/Bupropion SR and Placebo in Overweight and Obese Subjects

PHASE3CompletedINTERVENTIONAL
Enrollment

1,742

Participants

Timeline

Start Date

October 31, 2007

Primary Completion Date

May 31, 2009

Study Completion Date

May 31, 2009

Conditions
ObesityOverweight
Interventions
DRUG

Naltrexone SR 16 mg/Bupropion SR 360 mg /day

DRUG

Naltrexone SR 32 mg/Bupropion SR 360 mg /day

DRUG

Placebo

BEHAVIORAL

Ancillary therapy

Ancillary therapy consisting of diet instruction, advice on behavior modification, and exercise counseling

Trial Locations (34)

21209

Health Trends Research, LLC, Baltimore

27612

Wake Research Associates, LLC, Raleigh

28211

Center for Nutrition and Preventive Medicine, Charlotte

30308

Georgia Clinical Research, Atlanta

30909

CSRA Partners in Health, Inc, Augusta

33024

University Clinical Research, Pembroke Pines

33143

Miami Research Associates, Miami

35209

Radiant Research, Birmingham

36532

SelfCenter, PC, Fairhope

38018

Internal Medicine Associates of Cordova, Cordova

38305

Jackson Clinic, PA, Jackson

40509

Central Kentucky Research Associates, Inc., Lexington

43213

Central Ohio Nutrition Center, Inc., Columbus

44122

Rapid Medical Research, Inc., Cleveland

47713

Welborn Clinic, Evansville

60610

Radiant Research, Chicago

66202

Radiant Research Kansas City, Overland Park

70458

Medical Research Institute, Slidell

70808

Pennington Biomedical Research Center, Baton Rouge

73112

Lynn Health Science Institute, Oklahoma City

75231

Radiant Research, Dallas

75246

Baylor Endocrine Center, Dallas

78217

Radiant Research, San Antonio

78218

Oakwell Clinical Research, San Antonio

78752

Covance Clinical Research Unit Austin, Austin

85225

Radiant Research, Phoenix Southeast, Chandler

89557

Center for Nutrition and Metabolic Disorders, Reno

92130

Scripps Clinic Del Mar, San Diego

92161

VA San Diego Healthcare System, San Diego

92801

Advanced Clinical Research Institute, Anaheim

92869

Advance Clinical Research Institute, Orange

96814

East-West Medical Research Institute, Honolulu

97210

Summit Research Network (Oregon), Inc., Portland

01103

FutureCare Studies, Springfield

Sponsors
All Listed Sponsors
lead

Orexigen Therapeutics, Inc

INDUSTRY