Comparison of Alemtuzumab and Rebif® Efficacy in Multiple Sclerosis, Study One

PHASE3CompletedINTERVENTIONAL
Enrollment

581

Participants

Timeline

Start Date

August 31, 2007

Primary Completion Date

April 30, 2011

Study Completion Date

April 30, 2011

Conditions
Multiple Sclerosis, Relapsing-Remitting
Interventions
BIOLOGICAL

Alemtuzumab

Alemtuzumab 12 milligram (mg) per day intravenous (IV) infusion on 5 consecutive days at Month 0, followed by alemtuzumab 12 mg per day IV infusion on 3 consecutive days at Month 12.

BIOLOGICAL

Interferon beta-1a

Interferon beta-1a 44 microgram (mcg) subcutaneously 3-times weekly for 24 months. Dose adjustment was done as per Investigator's discretion.

Trial Locations (101)

3050

Royal Melbourne Hospital, Department of Neurology, Ward 4 East, Parkville

3065

St Vincent's Hospital, Fitzroy

3084

Austin Health, Heidelberg

4066

The Wesley Research Institute, Auchenflower

7000

Royal Hobart Hospital, Hobart

Unknown

North Central Neurology Associates, P.C., Cullman

Barrow Neurological Institute, St. Joseph's Hospital & Medical Center, Phoenix

Mayo Clinic Arizona, Scottsdale

Northwest NeuroSpecialists, PLLC, Tucson

Advanced Neurosciences Research, Fort Collins

Neurological Associates, Pompano Beach

Axiom Clinical Research of Florida, Tampa

Idaho Falls Multiple Sclerosis Center, PLLC, Idaho Falls

Consultants in Neurology, Ltd., Northbrook

Fort Wayne Neurological Center, Fort Wayne

University of Kansas Medical Center, Kansas City

MidAmerican Neuroscience Institute, Lenexa

Associates in Neurology, PSC, Lexington

University of Louisville Research Foundation, Louisville

Louisiana State University Health Sciences Center, Shreveport

UMass Memorial Medical Center, Worcester

University of Michigan Health System, Ann Arbor

Wayne State University, Detroit

University of Nevada School of Medicine, Las Vegas

Dartmouth-Hitchcock Medical Center, Lebanon

University of New Mexico, Health Sciences Center, MS Specialty Clinic, Albuquerque

Empire Neurology, Latham

Comprehensive Multiple Sclerosis Care Center at South Shore Neurologic Associates, P.C., Patchogue

University of Rochester Medical Center, Rochester

Carolinas Medical Center (CMC), Neurosciences & Spine Institute (NSSI), Charlotte

The Ohio State University Medical Center, Multiple Sclerosis Center, Columbus

Oak Clinic for Multiple Sclerosis, Uniontown

MS Center of Oklahoma, Oklahoma City

Lehigh Valley Hospital Neurosciences and Pain Research, Allentown

Advanced Neurosciences Institute, Franklin

Biomedical Research Alliance of NY, LLC, Franklin

Hope Neurology PC, Knoxville

Baylor College of Medicine, Maxine Mesinger MS Clinic, Houston

Central Texas Neurology, Round Rock

Integra Clinical Research, San Antonio

Neurology Center of San Antonio, San Antonio

DIABAID, Buenos Aires

Griffith University School of Medicine, Southport

The Queen Elizabeth Hospital, Woodville South

Concord Repatriation General Hospital, Concord

Westmead Hospital, Westmead

Hospital da Restauracao, Av Governador Agamenon Magalhaes, Recife

Hospital Sao Lucas PUC-RS, Porto Alegre

Hospital de Clínicas USP, São Paulo

University of Calgary and Foothills Medical Cenre, Calgary

UBC Hospital, Vancouver

The Ottawa Hospital, General Campus, Ottawa

Clinique Nuero-outaouais, Gatineau

Clinique Neuro rive-sud, Recherche Sepmus, Inc., Greenfield Park

Clinical Hospital Centre Rijeka, Rijeka

General Hospital Varazdin, Varaždin

"Clinical Hospital Centre Sestre Milosrdnice", Zagreb

Clinical Hospital Centre Zagreb, Zagreb

"General Hospital Sveti Duh", Zagreb

Department of Neurology, 1st Faculty of Medicine and General Teaching Hospital, Prague

Krajska zdravotni a.s., Hospital Teplice, Teplice

Hopital Purpan, Toulouse

Judisches Krankenhaus Berlin, Berlin

Universitätsklinik Carl Gustav Carus Dresden, Dresden

Klinikum der Goethe Universität Frankfurt, Frankfurt

Medizinische Hochschule Hannover, Hanover

Oberhavelkliniken Hennigsdorf, Hennigsdorf

Asklepios Klinikum Brandenburg, Teupitz

Hospital Angeles del Pedregal, Camino de Santa Teresa, Mexico City

Hospital Medica Sur CIF-BIOTEC, Mexico City

Clinical Neurology Centre Sp. z o.o. (Ltd), Krakow

Independent Public Healthcare Facility, Norbert Barlicki University Hospital No. 1 of the Medical University of Lodz, Lodz

Independent Public Teaching Hospital No. 4 in Lublin, Lublin

Heliodor Swiecicki Teaching Hospital of the Poznan University of Medical Sciences, Poznan

"Research Medical Complex Your Health Ltd", Kazan'

Moscow City Hospital #11, Moscow

Moscow State Medical Institution City Clinical Hospital #11, Moscow

Scientific Neurology Center RAMS, Moscow

Municipal City Hospital #33, Nizhny Novgorod

Federal State Institution Siberian Rettitorial Medical Center under Federal Medical-Biological Agency of Russia, Novosibirsk

City Clinical Hospital #2, Pyatigorsk

Institute of Human Brain RAS, Saint Petersburg

Nikolaevskaya Hospital, Saint Petersburg

St. Petersburg Pavlov State Medical University, Saint Petersburg

Samara Regional Clinical Hospital n.a. Kalinin, Samara

State Medical Institution: Republican Clinical Hospital n.a. G.G. Kuvatov, Ufa

Clinical Centre Serbia, Institute for Neurology, Belgrade

Military Medical Academy, Belgrade

Clinical centre Kragujevac, Kragujevac

Clinical Center Nis, Clinic for neurology, Niš

Clinical Centre of Vojvodina, Clinic for neurology, Novi Sad

Sahlgrenska University Hospital, Gothenburg

Chernihiv Regional Hospital, Chernihiv

Institute of Neurology, Psychiatry and Narcology under the Academy of Medical Sciences of Ukraine, Department of Neuroinfection and Multiple Sclerosis, Kharkiv

Hospoital of the Directorate of the Medical Corps within the Ukrainian Security Service, Neurology Department, Kyiv

Kyiv Municipal Clinical Hospital #4, Kyiv

Danylo Halytsky Lviv National Medical University, Lviv

Department Of Neurosciences, Addenbrookes Hospital, Cambridge

Centre for Neuroscience & Trauma, Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, London

University Hospital of Wales, Cardiff

Royal Hallamshire Hospital, Sheffield

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Bayer

INDUSTRY

lead

Genzyme, a Sanofi Company

INDUSTRY