Phase II Study for Previously Untreated Subjects With Non Small Cell Lung Cancer (NSCLC) or Small Cell Lung Cancer (SCLC)

PHASE2CompletedINTERVENTIONAL
Enrollment

334

Participants

Timeline

Start Date

February 29, 2008

Primary Completion Date

October 31, 2009

Study Completion Date

December 31, 2011

Conditions
Lung CancerSmall Cell Lung CancerCarcinoma, Non-Small-Cell Lung
Interventions
DRUG

Ipilimumab

Ipilimumab, 10 mg/kg, administered as a single-dose, intravenously (IV), over 90 minutes depending on randomization every 3 weeks (up to 6 doses). Participants could receive additional maintenance ipilimumab at a dose of 10 mg/kg every 12 weeks starting 24 weeks after the first ipilimumab dose.

DRUG

Placebo

Matched placebo for ipilimumab administered as a single dose IV over 90 minutes every 3 weeks (up to 6 doses) as part of induction. Participants could also receive additional maintenance placebo administered IV over 90 minutes every 12 weeks starting 24 weeks after the first placebo dose.

DRUG

Paclitaxel

175 mg/m\^2, administered as a single IV dose over 3 hours every 3 weeks (up to 6 doses). Dose modifications (reductions as well as delays) done as per product label.

DRUG

Carboplatin

Area under the concentration curve (AUC)=6, administered as a single IV dose over 30 minutes every 3 weeks (up to 6 doses) as per randomization. Dose modifications (reductions as well as delays) done as per product label.

Trial Locations (72)

10017

Local Institution, New York

10143

Local Institution, Torino

13274

Local Institution, Marseille

14076

Local Institution, Caen

16132

Local Institution, Genova

18840

Guthrie Clinical Research, Sayre

19047

St. Mary Medical Center, Langhorne

21075

Local Institution, Hamburg

21740

The John R. Marsh Cancer Center, Hagerstown

22927

Local Institution, Großhansdorf

28025

Cmc-Northeast/ Northeast Oncology Associates, Concord

29150

Santee Hematology/Oncology, Sumter

30341

Georgia Cancer Specialists, Atlanta

32806

M D Anderson Cancer Center- Orlando, Orlando

35033

Local Institution, Rennes

35235

Birmingham Hematology & Oncology Assoc. Llc, Birmingham

41701

Kentucky Cancer Clinic, Hazard

43235

Hematology Oncology Consultants, Inc, Columbus

44718

Gabrail Cancer Center, Canton

44791

Local Institution, Bochum

46023

Local Institution, Kharkiv

Local Institution, Ternopil

49102

Local Institution, Dnipropetrovsk

51109

Local Institution, Cologne

53100

Local Institution, Siena

55131

Local Institution, Mainz

55455

The Cancer Center, Minneapolis

60068

Local Institution, Park Ridge

60637

University Of Chicago Medical Center, Chicago

79031

Local Institution, Lviv

79415

Southwest Cancer Treatment And Research Center, Lubbock

81675

Local Institution, München

83092

Local Institution, Donetsk

85259

Mayo Clinic, Scottsdale

85715

Acrc/Arizona Clinical Research Center, Inc., Tucson

88014

Local Institution, Uzhhorod

89135

Nevada Cancer Institute, Las Vegas

90016

Local Institution, Belfort

90025

The Angeles Clinic & Research Institute, Inc, Los Angeles

90640

Oncology Care Medical Associates, Montebello

92123

Sharp Clinical Oncology Research, San Diego

92501

Compassionate Cancer Care Medical Group, Riverside

92708

Compassionate Cancer Care Medical Group, Inc., Fountain Valley

92879

Compassionate Cancer Care Medical Group, Corona

96250

Local Institution, Ebensfeld

105077

Local Institution, Moscow

115478

Local Institution, Moscow

125284

Local Institution, Moscow

153013

Local Institution, Ivanovo

163045

Local Institution, Arkhangelsk

190005

Local Institution, Saint Petersburg

194044

Local Institution, Saint Petersburg

194291

Local Institution, Saint Petersburg

197022

Local Institution, Saint Petersburg

198255

Local Institution, Saint Petersburg

354057

Local Institution, Sochi

357502

Local Institution, Pyatigorsk

380009

Local Institution, Navrangpura, Ahmedabad

454087

Local Institution, Chelyabinsk

500082

Local Institution, Hyderabad

576104

Local Institution, Manipal

632004

Local Institution, Vellore

695011

Local Institution, Trivandrum

02114

Massachusetts General Hospital, Boston

03756

Dartmouth-Hitchcock Medical Center, Lebanon

01640

Local Institution, Coswig

06120

Local Institution, Halle

04103

Local Institution, Leipzig

80-952

Local Institution, Gdansk

31-826

Local Institution, Krakow

10-513

Local Institution, Olsztyn

70-891

Local Institution, Szczecin

Sponsors
All Listed Sponsors
lead

Bristol-Myers Squibb

INDUSTRY