P-glycoprotein Inhibition as Adjunct Treatment for Medically Refractory Epilepsy.

PHASE2/PHASE3TerminatedINTERVENTIONAL
Enrollment

6

Participants

Timeline

Start Date

December 31, 2008

Primary Completion Date

October 31, 2010

Study Completion Date

October 31, 2010

Conditions
Epilepsy
Interventions
DRUG

Carvedilol-CR

Week 1: 20mg capsule once daily Week 2-3: 40mg capsule once daily Week 4-15: 80mg once daily Week 16: tapering (40mg/day x 4d, then 20mg/day x 3d), unless the patient wishes to continue receiving the medication.

Trial Locations (1)

10032

Columbia Comprehensive Epilepsy Center, New York

Sponsors
All Listed Sponsors
collaborator

American Epilepsy Society

OTHER

collaborator

Milken Institute

OTHER

collaborator

GlaxoSmithKline

INDUSTRY

lead

Columbia University

OTHER